产品货号：
Z19243
中文名称：
KEAP1抗体
英文名称：
Anti-KEAP1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KEAP1 Antibody |
| 指标别名 | Cytosolic inhibitor of Nrf2;INrf2;KEAP1;Kelch like protein 19;KIAA0132;KLHL19 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | KEAP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human KEAP1 recombinant protein (Position:K84-K312). |
| 实际分子量 | 66～72KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | KEAP1 (KELCH-LIKE ECH-ASSOCIATED PROTEIN 1),is a protein that in humans is encoded by the Keap1 gene.The KIAA0132 gene is mapped on 19p13.2.Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR),or Kelch,module.Keap1 has been shown to interact with Nrf2,a master regulator of the antioxidant response,which is important for the amelioration of oxidative stress.In the presence of the electrophilic agent diethylmalate,Nrf2 activity is released from Keap1 and Nrf2 translocate to the nucleus.Under quiescent conditions,Nrf2 is anchored in the cytoplasm through binding to Keap1,which,in turn,facilitates the ubiquitination and subsequent proteolysis of Nrf2.Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response,and Keap1 represses Nrf2 activation,Keap1 has become a very attractive drug target. |
| Uniprot ID | Q14145 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | kelch like ECH associated protein 1 |
| 蛋白名全称 | Kelch-like ECH-associated protein 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
相关搜索：KEAP1抗体，KEAP1多抗，Anti-KEAP1 Antibody